The University of Maine at Presque Isle is accredited by the New England Association of Schools and Colleges, Inc., which is one of six nationally recognized regional accrediting associations and is the official accrediting agency for schools and colleges in the six New England states. Institutional membership in the Association indicates that the University of Maine at Presque Isle has been carefully evaluated and found to meet standards agreed upon by qualified educators.

In addition, several academic programs within the University are accredited by specific agencies: viz., all Teacher Education programs by the Maine Department of Education, the Medical Laboratory Technology-Associate Degree program by the National Accrediting Agency for Clinical Laboratory Sciences, the Social Work program by the Council of Social Work Education and the Athletic Training Education program is accredited by the Commission on Accreditation of Athletic Training Education.